An impact of nanocrystals on dissolution rate of Lercanidipine: Supersaturation and crystallization by addition of solvent to antisolvent

Abstract Background Nanocrystals of any drug are pure solid particles with a mean diameter in nanometer range. Dissolution is crucial factor for absorption medicine case water-insoluble or poorly soluble drugs. The aim this study was to develop nanocrystals hydrophobic drug, Lercanidipine, by addition solvent an antisolvent high-speed homogenization achieve dissolution and solubility enhancement. Addition organic results genesis nanosized due fast nucleation process rapid mixing. nanosuspension formulated using PVP K30 as stabilizer. Further, nanosuspensions were lyophilized convert into mannitol cryoprotectant. developed characterized particle size, zeta potential, saturation solubility, vitro studies. Lyophilized FTIR, SEM, XRD, potential (ζ). Results Central composite design executed influence amount stabilizer ratio (independent variables) on size % release at 10 min (dependent variables). the Lercanidipine observed range 302.00 ± 10.58 484.33 6.51 nm measured Zetatrac. A considerable increase found rate compared drug. from increased up 88.95% within which only 21.53%. X-ray diffraction showed sharp distinct peaks increse crystallinity Particle morphology studied scanning electron microscopy revealed that nanoprecipitated lyophilization presence exhibited dendrite needle-like crystals. Conclusion nanocrystal development precipitation procedure methanol solvent, water antisolvent, low amounts very promising effective method Lercanidipine. Graphical abstract